Programme
The Master involves many highly reputed lecturers, coming from both Pharmaceutical Companies and highly qualified European Universities. The topics are related to the following areas:
Drug Design
- In silico Drug Design. Ligand- and structure-based drug design; virtual screening in medicinal chemistry; pattern recognition techniques applied to drug design.
- Developability Criteria in Pharmaceutical Industries. ADME parameters: in silico prediction and in vitro evaluation. Computational Methods for Drug-Likeness.
- Preliminary evaluation of new hits. Radioligand binding assays.
Advanced Organic Synthesis
- Protective groups in organic chemistry.
- Organo-metallic Chemistry in Organic Synthesis. Transition metal chemistry
- Asymmetric synthesis. Asymmetric synthesis and catalysis
- Radiochemistry. PET ligands developement.
Drug Discovery from Medicinal Plants
- Recent advance in natural drugs. The process of Drug Discovery from plants: a historical overview. From raw materials to production of active principles, derivatives, extracts and ingredients of botanical origin. Preparation of dynamic libraries of natural molecules. Biomimetic synthesis.
- Drugs of Natural Origin Development. Discovery and identification of new active principles derived from plants for pharmaceuticals. The concerns involved in creating a proper formulation of extracts. The main regulatory issues for drugs and dietary supplements of botanical origin in the major markets of Europe, USA and Japan.
New Methods of Synthesis in Medicinal Chemistry
- Synthesis and Analysis in Combinatorial Chemistry. Solid Phase Organic Synthesis. Libraries purification. The main analitycal techniques in combinatorial chemistry.
- Polymer Assisted Solution Phase Synthesis. Application of PASPS in medicinal chemistry. Laboratory work.
- Microwave Assisted Organic Synthesis. Application of MAOS in medicinal chemistry. Synthesis of compound libraries for lead identification. Combined Ultrasound and Microwave- Assisted Organic Synthesis in drug discovery. Laboratory work.
- Flow Chemistry e Click Chemistry. New tools for a fast preparation of compound libraries. Laboratory work.
Chiral Compounds in Medicinal Chemistry
- Preparation an Characterization of Chiral Drugs. Chirality and drugs. Resolution of chiral compounds; Dutch Resolution; chiral chromatographic resolution; enantioselective chromatographic resolution in pharmaceutical industry. Configurational assignement methodologies.
Biocatalysis and Drug Development
- Biocatalytic Drug Development. Enzyme catalysis; enzyme-catalyzed reactions. Immobilized enzymes. Application of biocatalytic processes in pharmaceutical industry.
Advanced Medicinal Chemistry
- New topics in medicinal chemistry
- Patentability of drug candidates.
- Preclinical development of drugs.
- Clinical monitoring.
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